New Delhi: Single vaccine with double dose measles vaccine may be up to 2.6 times more likely to occur altogether ineffective In Children born by C-stream, compared to those born naturally, new research has found. Researchers said that vaccine failure means the child’s immune system Does not produce antibodies to fight measles infection, and therefore, remains susceptible to the disease.

A possible reason for the vaccine being ineffective may be related to the baby’s development. gut microbiomeThe researchers said.

Previous studies have shown that vaginal or natural birth He said it transfers a large number of germs from mother to child, thereby boosting the infant’s immune system.

study by Cambridge UniversityThe UK and Fudan University, China also found that a second dose of measles produced stronger immunity against the viral disease in babies born by cesarean or C-section, which involves cutting into the mother’s abdomen and uterus to deliver the baby. Is included.

“We have found that the way we are born – either by C-section or by natural birth – has a long-term impact on our immunity to diseases as we grow up,” said Henrik Salje, from the Department of Genetics at the University of Cambridge. and joint senior author of the study published in the journal Nature Microbiology.

Measles is an acute and highly contagious viral disease, occurring primarily in children. Symptoms may include high fever, cough, runny nose and a rash all over the body. According to the World Health Organization, a two-dose vaccination is the best way to avoid getting sick and spreading the disease.

Using data from previous studies of more than 1,500 children in Hunan, China, researchers found that 12 percent of babies born via C-section had no immune response after their first measles vaccination, compared with 12 percent of those born vaginally. Distribution compared to 5 percent of children born.

Researchers said many children are unable to get a second measles vaccine, which could be dangerous for them and the broader population.

“We really want to monitor babies born by C-section to make sure they get the second measles vaccine because their first vaccine is more likely to fail,” Salje said.

The researchers said that increasingly women around the world are giving birth by C-section, due to which the babies are not exposed to the mother’s microbiome, as is the case during vaginal birth.

“We think this means they take longer to develop their gut microbiome as well as the immune system’s ability to respond to vaccines against diseases, including measles,” Salje said. ”